Angiotensin II Activates the RhoA Exchange Factor Arhgef1 in Humans
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چکیده
منابع مشابه
Angiotensin II activates the RhoA exchange factor Arhgef1 in humans.
Although a causative role for RhoA-Rho kinase has been recognized in the development of human hypertension, the molecular mechanism(s) and the RhoA guanine exchange factor(s) responsible for the overactivation of RhoA remain unknown. Arhgef1 was identified as a RhoA guanine exchange factor involved in angiotensin II (Ang II)-mediated regulation of vascular tone and hypertension in mice. The aim...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2015
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.114.05065